+1. The c/c does not lift w/o a reason. Has the panel ever been painted, other than at the factory? What year is the car? Daily driver or a classic? I know GM's in the 80's (?) had c/c peeling badly on the horizontal surfaces. Either a contaminant (brake fluid, egg) got onto the paint and ate it from above or the issue is coming up from below.
If the issue came from above, it's possible to spot-paint the c/c "burn in the clear" and most paint manufacturers have a specific procedure and product for this. However, it's not the ideal way to go. The c/c will likely be visible at the edges where the new c/c meets the old in time, it may take a couple of years to show but it will likely eventually show.
It is a 2005..and it's white..I think I am going to try to blend it before I get the entire quarter redone
To c/c the entire panel is no big deal, unless there is not a hard break or body line where the 1/4 meets the roof. It just needs to be scuffed, detrimmed & masked off, etc. The panel does not need to be stripped of all paint, unless the failure was due to the substrate or color coat.
Is the c/c on the car faded? If so, to c/c the entire panel would cause a appearance difference between the new gloss and the faded c/c.